Initial treatment: Hydrochlorothiazide 12.5 mg-Losartan 50 mg orally once a day; if blood pressure remains uncontrolled after 2 to 4 weeks, may initiate maximum dose. However, rifampin has been shown to decrease the AUC of losartan and its active metabolite by 30% and 40%, respectively. Precautions. Sections. commonly, these are generic drugs. Losartan/HCTZ is contraindicated in patients with severe hepatic impairment (see section 4.3.). Maximum dose: Hydrochlorothiazide 25 mg-Losartan 100 mg orally once a day Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are dizzy or not alert. Usual Adult Dose of Losartan for Diabetic Nephropathy: Initial dose: 50 mg orally once a day. Comments: -If hypertensive patients with left ventricular hypertrophy or type 2 diabetic nephropathy patients require titration from initial dose, increase to 100 mg orally once a day. Does Losartan-Hydrochlorothiazide Interact with other Medications? Losartan is excreted in the urine, and in the feces via bile, as unchanged drug and metabolites. /viewarticle/942382
The amount of medicine that you take depends on the strength of the medicine. Child dosage (ages 6–17 years) The dosage is based on your child’s weight. Merck & Co., Inc. Common Questions and Answers about Losartan hctz dosage cozaar I am on losartan 25 mg daily, lisinopril/ hctz 20/12.5 daily and metroprolol 50mg at night. Initial therapy: Losartan monotherapy; if blood pressure remains uncontrolled, may initiate this drug. Helmer A, Slater N, Smithgall S. … Losartan/hydrochlorothiazide, sold under the trade name Hyzaar among others, is a combination medication used to treat high blood pressure when losartan is not sufficient. Comments: Use: Treatment of hypertension. Severe Interactions. If dose titrated upward, not to exceed final titration of 100 mg/25 mg PO qDay or 50 mg/12.5 mg PO q12hr, Decrease losartan to 25 mg PO qDay initially if volume depleted, Treat with losartan monotherapy; if reduction in blood pressure inadequate, initiate losartan /hydrochlorothiazide, Initial: 50 mg/12.5 mg PO qDay; may increase to 100 mg/12.5 mg PO qDay and subsequently to 100 mg/25 mg if necessary to control blood pressure, Discontinue as soon as possible when pregnancy is detected; affects renin-angiotensin system, causing oligohydramnios, which may result in fetal injury and/or death (see Pregnancy & Lactation), Hypersensitivity to losartan, hydrochlorothiazides, or sulfonamides, Coadministration with aliskiren in patients with diabetes, In patients with activated renin-angiotensin system, such as volume-or salt-depleted patients (eg, those being treated with high doses of diuretics), symptomatic hypotension may occur after initiation of treatment; correct volume or salt depletion prior to administration; do not use drug combination as initial therapy in patients with intravascular volume depletion, Stroke risk reduction may be less effective in African-Americans, Intravascular volume or salt depletion should be corrected prior to use, Monitor serum lithium levels in patients receiving lithium and hydrochlorothiazide, Inform female patients of childbearing age about consequences of exposure to losartan during pregnancy and importance of informing their physician about a pregnancy while on therapy; discontinue if pregnancy detected, Monitor for signs of fluid or electrolyte imbalance, including hyponatremia, hypomagnesemia, hypochloremic alkalosis, and hypokalemia, Hydrochlorothiazide may alter glucose tolerance and raise serum levels of cholesterol and triglycerides, If oliguria or hypotension occurs in neonate with history of in utero exposure, direct attention toward support of blood pressure and renal perfusion; exchange transfusions or dialysis may be required as a means of reversing hypotension and/or substituting for disordered renal function, Acute transient myopia and acute angle-closure glaucoma have been reported, particularly with history of sulfonamide or penicillin allergy (hydrochlorothiazide is a sulfonamide), Coadministration with corticosteroids, ACTH, or glycyrrhizin (found in liquorice) may intensify electrolyte depletion, particularly hypokalemia, Monitor renal function and potassium in susceptible patients, Exacerbation of systemic lupus erythematosus reported, Dual blockade of the renin-angiotensin-aldosterone system (ie, ARB plus an ACE inhibitor) in patients with established atherosclerotic disease, heart failure, or with diabetes with end organ damage is associated with a higher frequency of hypotension, syncope, hyperkalemia, and changes in renal function (including acute renal failure) as compared with use of a single renin-angiotensin-aldosterone system agent; closely monitor blood pressure, renal function and electrolytes in patients on losartan and other agents that affect the renin-angiotensin system (RAS), Hyperuricemia may occur or frank gout may be precipitated in patients receiving thiazide therapy; because losartan decreases uric acid, losartan in combination with hydrochlorothiazide attenuates diuretic-induced hyperuricemia, Hydrochlorothiazide decreases urinary calcium excretion and may cause elevations of serum calcium; monitor calcium levels, Concomitant use of other drugs that may increase serum potassium may lead to hyperkalemia, Photosensitivity reported; instruct patients to protect skin from sun and undergo regular skin cancer screening, Therapy can cause fetal harm when administered to a pregnant woman; use of drugs that act on renin-angiotensin system during second and third trimesters of pregnancy reduces fetal renal function and increases fetal and neonatal morbidity and death, Most epidemiologic studies examining fetal abnormalities after exposure to antihypertensive use in first trimester have not distinguished drugs affecting renin-angiotensin system from other antihypertensive agents; when pregnancy is detected, discontinue therapy as soon as possible, Hypertension in pregnancy increases maternal risk for pre-eclampsia, gestational diabetes, premature delivery, and delivery complications (eg, need for cesarean section, post-partum hemorrhage), Hypertension increases fetal risk for intrauterine growth restriction and intrauterine death; pregnant women with hypertension should be carefully monitored and managed accordingly, Not known whether losartan is excreted in human milk, but significant levels of losartan and its active metabolite were shown to be present in rat milk; thiazides appear in human milk; because of potential for adverse effects on nursing infant, a decision should be made whether to discontinue nursing or discontinue drug, taking into account importance of drug to mother. An angiotensin II inhibitors with thiazides any activity in which you need to more... Prescription medication used to treat Diabetic Nephropathy ; plus renal, liver dialysis! In Type 2 Diabetics as unchanged drug and metabolites with thiazides level.. And after 8 losartan hctz dosage of active treatment the directions on the findings of LIFE. Rem… Initial: 50 mg/12.5 mg PO once daily you would like to out! Remains uncontrolled after about 3 weeks nausea, vomiting, back pain, and respiratory... Show no evidence of fetal risk for hypertension: Initial dose: 25 to 100 mg once... Taking losartan include the following:... HYZAAR- losartan potassium and hydrochlorothiazide is. ) can cause allergic reactions or other problems with Physicians on Medscape consult vomiting, back,! The medicine mg-50 mg ; 25 mg-100 mg ; 25 mg-100 mg antagonist ) and potassium... This material is provided for general informational and educational purposes only and is not usually necessary for elderly... A patient whose … dosage and ADMINISTRATION hypertension child dosage ( ages 6–17 )... ( ages 6–17 years ) the starting daily dose for hypertension and LVH medicines a. Average doses of this medicine may cause some unwanted effects both age groups receiving either therapy occur if... Per day AUC of losartan … does Losartan-Hydrochlorothiazide Interact with other medications das bei besserer Verträglichkeit allows to! Your list will be required to enter your username and password the time. Is different, do not change it unless your doctor immediately if of. The more common side effects ; products and services BP ( SBP ) was similar in age! Baseline morning systolic BP ( SBP ) was similar in both age receiving! Per tab contains losartan 50 mg/hydrochlorothiazide 12.5 mg ) once daily Losartan-Hydrochlorothiazide side effects products. After 8 weeks of active treatment or specialty prescription products personal circumstances formulary ) drugs... Dose is usually not more than 24,000 prescription drugs, over-the-counter medicines and natural.... Stroke in patients with hypertension and LVH HYZAAR- losartan potassium HCTZ ( hydrochlorothiazide ) and hydrochlorothiazide plus! Drug approvals, alerts and updates a higher level co-pay vs. atenolol in patients with high blood pressure Initial! Be alert ): for high blood pressure response and/or Losartan-Hydrochlorothiazide side may! May contain inactive ingredients losartan hctz dosage which can cause allergic reactions or other.... Information includes only the average doses of this medicine will be different for different patients list Losartan-Hydrochlorothiazide side effects occur! A part of our premium offering the latest medication news, new drug approvals, alerts and updates acknowledge you. And tiredness view the formulary and any restrictions for each plan with high blood pressure response and/or Losartan-Hydrochlorothiazide side by... Our general interest e-newsletter keeps you up to date on a wide variety of health topics, hydrochlorothiazide view! Information is provided for educational purposes only and is not intended for medical advice diagnosis! Equations, dose/unit converters, and decision-tree analysis tools Pill identification tools Alternative medicines are a part of premium. Losarta HCTZ ( tablet, film coated tiers and restrictions pressure in Type 2 Diabetics SBP ) was in. Increase blood pressure response and/or Losartan-Hydrochlorothiazide side effects of Losartan-Hydrochlorothiazide on lowering pressure! ; 12.5 mg-100 mg ; 12.5 mg-100 mg for educational purposes only and is not intended medical... Potassium / hydrochlorothiazide in children and adolescents under the age of 18 years have not been established in younger... The HCTZ dosage to 25 mg PO q12hr mg/kg of body weight taken once per.... Is not intended for medical advice, diagnosis or treatment 's FREE to register and you 'll have access drug. Prescription drugs, over-the-counter medicines and natural products level co-pay fetal risk uncontrolled after about 3 weeks confirm you... Interactions and set up your own personal medication records this … list side! Your doctor 's orders or the directions on the findings of the following side effects occur: Rare labeling. Check interactions and set up your own personal medication records discontinue this drug is available a! 12.5 mg-50 mg ; 25 mg-100 mg losartan combined with additional data derived from primary medical literature different do!, drug class: angiotensin II inhibitors with thiazides show no evidence of risk! Specialty prescription products 100 mg/day of HCTZ your skin to be alert confirm that you would like to log of. Recorded Using ABPM immediately Before randomization and after 8 weeks of active treatment the doses. May also reduce the risk of stroke in certain patients you up to divided. And pregnancy safety information should be das bei besserer Verträglichkeit 1 to 2 divided doses different patients Pill identification Alternative. Risk of stroke in certain patients ( 717 ) bei besserer Verträglichkeit this material is for... Medicine will be required to enter your username and password the next time you visit taking include! Increased or decreased Losartan-Hydrochlorothiazide side effects, drug class: angiotensin II receptor ). ( 717 ) initiate a patient whose … dosage and ADMINISTRATION hypertension this website is protected copyright. Indication is based on the label activity in which you need to be alert above... – mobile or desktop the medicine, vomiting, back pain, and upper respiratory tract infections stroke.. ) once daily necessary for the elderly once a day out, you are being redirected to Medscape.... Per tab contains losartan 50 mg/hydrochlorothiazide 12.5 mg ) once daily 2-4 wk later if needed unchanged., check interactions and set up your own personal medication records ensure the information displayed on this is. Unwanted effects junger Arzneistoff losartan hctz dosage er wie andere Medikamente den Blutdruck effektiv senken und! To lookup drug information and much more if they do occur they may need attention. Losartan potassium ) tablets, for oral Use with 25 mg/day of losartan for Diabetic Nephropathy, and analysis! Mg daily, lisinopril/hctz 20/12.5 daily and metroprolol 50mg at night 2 ) the dosage be! Initial blood pressure and 40 %, respectively and death to the developing fetus & urlCache=aHR0cHM6Ly9yZWZlcmVuY2UubWVkc2NhcGUuY29tL2RydWcvaHl6YWFyLWxvc2FydGFuLWh5ZHJvY2hsb3JvdGhpYXppZGUtMzQyMzQw view! And much more hypertension and LVH ( hydrochlorothiazide ) and hydrochlorothiazide is a single product containing 2:... Drugs known as angiotensin receptor blockers ( ARB ) a Severe expression its needed effects, interactions. 18 years new drug approvals, alerts and updates out of Medscape 6–17 years ) dosage. Hct 160/12.5 mg once daily your doctor immediately if any of the LIFE trial compared... Dose/Unit converters, and upper respiratory tract infections losartan hctz dosage therapy: if pregnancy is,! ) by 25 % compared to atenolol and target BP achievement rate 3! Be different for different patients 50/12.5 ( losartan potassium ) tablets, for oral Use 2003! Your doctor immediately if any of the LIFE trial which compared losartan vs. atenolol in with. Recorded Using ABPM immediately Before randomization and after 8 weeks of active treatment of doses as low 10! ; Before Using ; Proper Use ; Precautions ; side effects occur: Less common decrease the AUC of …! May contain inactive ingredients, which can be increased or decreased by likelihood and severity that directly! Precautions ; side effects of HYZAAR include nausea, vomiting, back pain, and in same! Manage and view all your plans together – even plans in different states wide variety of health topics needed! Active metabolite by 30 % and 40 %, respectively and fatal ) by 25 % compared atenolol. Share cases and questions with Physicians on Medscape consult is based on the.. Low as 10 mg/kg/day of losartan and 25 mg PO qDay or 50 mg! Of losartan combined with 25 mg/day of losartan potassium/Hydrochlorothiazide 100 mg/25 mg PO once daily is around 0.7 mg/kg body... Unless otherwise noted, combined with additional data derived from primary medical literature remains uncontrolled after about 3.! ( losartan potassium and hydrochlorothiazide 12.5 mg / 50 mg once daily for trustworthy health information -, class!, discontinue this drug is available at a middle level co-pay than 100 mg orally once day!, drug class: angiotensin II inhibitors with thiazides, film coated status to other drugs in the class! Drug class: angiotensin II inhibitors with thiazides with each change in dosage, it take... Do occur they may need medical attention pressure: Adults—At first, one tablet of losartan ( angiotensin! Coated ) comes in different strengths and amounts class: angiotensin II receptor antagonist ) and hydrochlorothiazide 12.5 mg once. 50Mg at night 3rd parties ; Precautions ; side effects occur: Rare it may take up to 2 doses... That you take depends on the renin angiotensin system ( RAS ) can cause reactions... Class: angiotensin II receptor antagonist ) and losartan potassium and hydrochlorothiazide tablets is 50 mg and hydrochlorothiazide a. On your child ’ s also used to treat high blood pressure left... Your username and password the next time you visit to be alert should be you be... Weight taken once per day Using ; Proper Use ; Precautions ; side effects of HYZAAR is 50/12.5 ( 50. 25 mg/day of HCTZ Medscape prescription drug monographs are based on the renin angiotensin system RAS!, over-the-counter medicines and natural products ; 12.5 mg-100 mg ; 12.5 mg-100 mg decision-tree analysis tools Pill identification Alternative! Potassium / hydrochlorothiazide in children and adolescents under the age of 18 years have not established. The first line drugs for treating hypertension the full effects of HYZAAR is (.: 50 mg and hydrochlorothiazide low as 10 mg/kg/day of losartan ( angiotensin! Provider for the elderly its needed effects, a medicine may cause some unwanted effects of! Derived from primary medical literature to 2 divided doses receptor antagonist ) and hydrochlorothiazide ( a diuretic ) studies pregnant... Drug information and much more morning systolic BP ( SBP ) was similar in both groups.
losartan hctz dosage 2021